Palladium-catalyzed aryl-aryl cross-coupling reaction using ortho-substituted arylindium reagents

被引:75
作者
Pena, Miguel A. [1 ]
Perez Sestelo, Jose [1 ]
Sarandeses, Luis A. [1 ]
机构
[1] Univ A Coruna, Dept Quim Fundamental, E-15071 La Coruna, Spain
关键词
D O I
10.1021/jo062148s
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A range of biaryl compounds (aryl-aryl, aryl-heteroaryl, and heteroaryl-heteroaryl) can be efficiently prepared by a palladium-catalyzed cross-coupling reaction between ortho-substituted triarylindium reagents and aryl halides. The triarylindium reagents are prepared by directed ortho-lithiation and transmetallation to indium from the corresponding benzene derivatives using various directed metallation groups (DMGs). The reaction proceeds smoothly in high yields and short reaction times with high atom economy (the three aryl groups attached to indium are efficiently transferred).
引用
收藏
页码:1271 / 1275
页数:5
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