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Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex

被引：149
作者：
Hansen, DS
Siomos, MA
Buckingham, L
Scalzo, AA
Schofield, L
机构：
[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
[2] Univ Western Australia, Dept Microbiol, Nedlands, WA 6907, Australia
来源：
IMMUNITY | 2003年 / 18卷 / 03期
关键词：
D O I：
10.1016/S1074-7613(03)00052-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
NKT cells are specialized cells coexpressing NK and T cell receptors. Upon activation they rapidly produce high levels of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) and are therefore postulated to influence T(H)1/T(H)2 immune responses. The precise role of the CD1/NKT cell pathway in immune response to infection remains unclear. We show here that CD1d-restricted NKT cells from distinct genetic backgrounds differentially influence TH1/TH2 polarization, proinflammatory cytokine levels, pathogenesis, and fatality in the P. berghei ANKA/rodent model of cerebral malaria. The functional properties of CD1d-restricted NKT cells vary according to expression of loci of the natural killer complex (NKC) located on mouse chromosome 6, which is shown here to be a significant genetic determinant of murine malarial fatalities.
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页码：391 / 402
页数：12
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