Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex

被引：149

作者：

Hansen, DS

Siomos, MA

Buckingham, L

Scalzo, AA

Schofield, L

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[2] Univ Western Australia, Dept Microbiol, Nedlands, WA 6907, Australia

来源：

IMMUNITY | 2003年 / 18卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(03)00052-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKT cells are specialized cells coexpressing NK and T cell receptors. Upon activation they rapidly produce high levels of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) and are therefore postulated to influence T(H)1/T(H)2 immune responses. The precise role of the CD1/NKT cell pathway in immune response to infection remains unclear. We show here that CD1d-restricted NKT cells from distinct genetic backgrounds differentially influence TH1/TH2 polarization, proinflammatory cytokine levels, pathogenesis, and fatality in the P. berghei ANKA/rodent model of cerebral malaria. The functional properties of CD1d-restricted NKT cells vary according to expression of loci of the natural killer complex (NKC) located on mouse chromosome 6, which is shown here to be a significant genetic determinant of murine malarial fatalities.

引用

页码：391 / 402

页数：12

共 56 条

[51] THE ROLE OF T(H)1 AND T(H)2 CELLS IN A RODENT MALARIA INFECTION [J].