Facile discrimination of aldose enantiomers by reversed-phase HPLC

被引：767

作者：

Tanaka, Takashi

Nakashima, Tatsuya

Ueda, Toshihisa

Tomii, Kenji

Kouno, Isao

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan

[2] Saga Univ, Fac Agr, Saga 8400027, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 06期

关键词：

aldose; absolute configuration; HPLC; cysteine; isothiocyanate;

D O I：

10.1248/cpb.55.899

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One-pot reactions of aldoses with L-Cysteine methyl ester and o-tolyl isothiocyanate yielded methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbamoyl)-thiazolidine-4(R)-carboxylates. Direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses. The reaction was applied to the determination of absolute configuration the sugar residues of an aroma precursor.

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页码：899 / 901

页数：3

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