Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics

被引：116

作者：

Sies, H ^{[1
]}

Arteel, GE ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Physiol Chem 1, D-40001 Dusseldorf, Germany

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2000年 / 28卷 / 10期

关键词：

ebselen; GSH peroxidase; peroxynitrite; plasma; oxidative stress; free radicals;

D O I：

10.1016/S0891-5849(00)00253-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxynitrite is an oxidant generated under inflammatory conditions, acting in defense against invading microorganisms. There is a need for protection of the organism from damage inflicted by peroxynitrite. Selenium-containing compounds, notably ebselen, have a high second-order reaction rate constant (approx. 2 x 10(6) M-1 s(-1)), which makes them candidates for efficient protection. This applies also for selenium in proteins, occurring as selenocysteine or selenomethionine residues. Glutathione peroxidases, thioredoxin reductase, and selenoprotein P have been shown to play a potential role in protection against peroxynitrite. Tellurium-containing compounds also react with peroxynitrite. (C) 2000 Elsevier Science Inc.

引用

页码：1451 / 1455

页数：5

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