Examination of the expanding pathways for the regulation of p21 expression and activity

被引：371

作者：

Jung, Yong-Sam ^{[1
]}

Qian, Yingjuan ^{[1
]}

Chen, Xinbin ^{[1
]}

机构：

[1] Univ Calif Davis, Ctr Comparat Oncol, Davis, CA 95616 USA

来源：

CELLULAR SIGNALLING | 2010年 / 22卷 / 07期

关键词：

p53; p21(Waf1/Cip1/Sdi); MicroRNA; RNA-binding proteins; mRNA stability; Transcription; RNA-BINDING PROTEIN; NUCLEOTIDE EXCISION-REPAIR; CYCLIN-DEPENDENT KINASES; CELL NUCLEAR ANTIGEN; CDK INHIBITOR P21; HISTONE DEACETYLASE INHIBITORS; P21(WAF1) MESSENGER-RNA; 3/P21; COMPLEX-FORMATION; PROLYL ISOMERASE PIN1; DNA-REPLICATION;

D O I：

10.1016/j.cellsig.2010.01.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

p21(Waf1/Cip1/Sdi1) was originally identified as an inhibitor of cyclin-dependent kinases, a mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required for proper cell cycle progression and plays a role in cell death, DNA repair, senescence and aging, and induced pluripotent stem cell reprogramming. Although transcriptional regulation is considered to be the initial control point for p21 expression, there is growing evidence that post-transcriptional and post-translational regulations play a critical role in p21 expression and activity. This review will briefly discuss the activity of p21 and focus on current knowledge of the determinants that control p21 transcription, mRNA stability and translation, and protein stability and activity. Published by Elsevier Inc.

引用

页码：1003 / 1012

页数：10

共 221 条

[11] A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint [J].

Beckerman, Rachel ;

Donner, Aaron J. ;

Mattia, Melissa ;

Peart, Melissa J. ;

Manley, James L. ;

Espinosa, Joaquin M. ;

Prives, Carol .

GENES & DEVELOPMENT, 2009, 23 (11) :1364-1377

[12] Effects of p21 deletion in mouse models of premature aging [J].

Benson, Erica K. ;

Zhao, Bo ;

Sassoon, David A. ;

Lee, Sam W. ;

Aaronson, Stuart A. .

CELL CYCLE, 2009, 8 (13) :2002-2004

[13] Involvement of p21Waf1/Cip1 in protein kinase C alpha-induced cell cycle progression [J].

Besson, A ;

Yong, VW .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (13) :4580-4590

[14] Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation [J].

Bloom, J ;

Amador, V ;

Bartolini, F ;

DeMartino, G ;

Pagano, M .

CELL, 2003, 115 (01) :71-82

[15] Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase [J].

Bornstein, G ;

Bloom, J ;

Sitry-Shevah, D ;

Nakayama, K ;

Pagano, M ;

Hershko, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (28) :25752-25757

[16] Requirement for p53 and p21 to sustain G2 arrest after DNA damage [J].

Bunz, F ;

Dutriaux, A ;

Lengauer, C ;

Waldman, T ;

Zhou, S ;

Brown, JP ;

Sedivy, JM ;

Kinzler, KW ;

Vogelstein, B .

SCIENCE, 1998, 282 (5393) :1497-1501

[17] NORE1A Tumor Suppressor Candidate Modulates p21CIP1 via p53 [J].

Calvisi, Diego F. ;

Donninger, Howard ;

Vos, Michele D. ;

Birrer, Michael J. ;

Gordon, Laura ;

Leaner, Virna ;

Clark, Geoffrey J. .

CANCER RESEARCH, 2009, 69 (11) :4629-4637

[18] Activation of protein kinase G increases the expression of p21CIP1, p27KIP1, and Histidine triad protein 1 through Sp1 [J].

Cen, Bo ;

Deguchi, Atsuko ;

Weinstein, I. Bernard .

CANCER RESEARCH, 2008, 68 (13) :5355-5362

[19] The second BRCT domain of BRCA-1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter [J].

Chai, YL ;

Cui, JQ ;

Shao, NS ;

Reddy, ESP ;

Rao, VN .

ONCOGENE, 1999, 18 (01) :263-268

[20]

Chan TA, 2000, GENE DEV, V14, P1584

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