Chemical Genomic Approaches to Study Model Microbes

被引：17

作者：

Barker, Courtney A. ^{[1
,2
]}

Farha, Maya A. ^{[1
,2
]}

Brown, Eric D. ^{[1
,2
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Michael G DeGroote Inst Infect Dis Res, Hamilton, ON L8N 3Z5, Canada

来源：

CHEMISTRY & BIOLOGY | 2010年 / 17卷 / 06期

基金：

加拿大健康研究院;

关键词：

SACCHAROMYCES-CEREVISIAE GENOME; ESCHERICHIA-COLI; DRUG DISCOVERY; STAPHYLOCOCCUS-AUREUS; EXPRESSION PROFILES; PSEUDOMONAS-AERUGINOSA; TARGET IDENTIFICATION; SMALL MOLECULES; COMPOUND-MODE; BETA-LACTONES;

D O I：

10.1016/j.chembiol.2010.05.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent genome-scale analyses of genetic interactions in model microbes have revealed the inherent functional organization of the cell as a dense network of highly interconnected pathways. While classical one gene at a time paradigms offer limited insight into cellular systems, genome-scale approaches are making considerable headway. Indeed, where small organic compounds are ideal probes of biological complexity, systematic chemical genomic methods are emerging as requisite and powerful approaches to describing both the small molecule probe and network with which it interacts. Here, we highlight various chemical genomic approaches that are being pioneered in model microbes.

引用

页码：624 / 632

页数：9

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