Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review

被引：190

作者：

Fain, John N. ^{[1
]}

机构：

[1] Univ Tennessee, Dept Mol Sci, Hlth Sci Ctr, Memphis, TN 38163 USA

来源：

MEDIATORS OF INFLAMMATION | 2010年 / 2010卷

关键词：

NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; TOLL-LIKE RECEPTOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PLASMINOGEN-ACTIVATOR INHIBITOR-1; DEPOT-SPECIFIC DIFFERENCES; MESSENGER-RNA EXPRESSION; BODY-FAT DISTRIBUTION; NERVE GROWTH-FACTOR; INSULIN-RESISTANCE;

D O I：

10.1155/2010/513948

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This paper considers the role of putative adipokines that might be involved in the enhanced inflammatory response of human adipose tissue seen in obesity. Inflammatory adipokines [IL-6, IL-10, ACE, TGF beta 1, TNF alpha, IL-1 beta, PAI-1, and IL-8] plus one anti-inflammatory [IL-10] adipokine were identified whose circulating levels as well as in vitro release by fat are enhanced in obesity and are primarily released by the nonfat cells of human adipose tissue. In contrast, the circulating levels of leptin and FABP-4 are also enhanced in obesity and they are primarily released by fat cells of human adipose tissue. The relative expression of adipokines and other proteins in human omental as compared to subcutaneous adipose tissue as well as their expression in the nonfat as compared to the fat cells of human omental adipose tissue is also reviewed. The conclusion is that the release of many inflammatory adipokines by adipose tissue is enhanced in obese humans.

引用

页数：20

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