A highly acid labile silicon linker for solid phase synthesis

被引：43

作者：

Hone, ND

Davies, SG

Devereux, NJ

Taylor, SL

Baxter, AD

机构：

[1] Oxford Divers, Abingdon OX14 4RX, Oxon, England

[2] Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(97)10650-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel arylsilane based linker has been prepared for the solid phase synthesis of small molecule combinatorial libraries. Efficient cleavage is achieved using TFA via anchimerically assisted protiodesilylation to yield aromatic products possessing no residual linker functionality. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：897 / 900

页数：4

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