Practical ruthenium/lipase-catalyzed asymmetric transformations of ketones and enol acetates to chiral acetates

被引：61

作者：

Jung, HM ^{[1
]}

Koh, JH ^{[1
]}

Kim, MJ ^{[1
]}

Park, J ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, POSTECH, Dept Chem, Div Mol & Life Sci, Pohang 790784, South Korea

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 16期

关键词：

D O I：

10.1021/ol006169z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Ketones were asymmetrically transformed to chiral acetates by one-pot processes using a lipase and an achiral ruthenium complex under 1 atm of hydrogen gas in ethyl acetate. Molecular hydrogen was also effective for the transformation of enol acetates to chiral acetates without additional acyl donors with the same catalyst system.

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收藏

页码：2487 / 2490

页数：4

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