Dissolved Core Alginate Microspheres as "Smart-Tattoo" Glucose Sensors

被引：1

作者：

Chaudhary, Ayesha ^{[1
]}

Raina, Monica ^{[1
]}

McShane, Michael J. ^{[2
]}

Srivastava, Rohit ^{[1
]}

机构：

[1] Indian Inst Technol, Sch Biosci & Bioengn, Bombay 400076, Maharashtra, India

[2] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA

来源：

2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20 | 2009年

基金：

美国国家科学基金会;

关键词：

AFFINITY SENSOR; NANOFILM COATINGS; CONCANAVALIN-A; BLOOD-GLUCOSE; BINDING; OXIDASE; ENCAPSULATION; MICROCAPSULES; PERFORMANCE; BIOSENSORS;

D O I：

10.1109/IEMBS.2009.5334597

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The feasibility of multilayer thin film coated dissolved-core alginate-templated microsphere sensors based on fluorescence resonance energy transfer and competitive binding, was explored in simulated interstitial fluid, using glucose as a model analyte. The glucose sensitivity was observed to be 0.89%/mM glucose with a linear response in the range of 0-50mM glucose. The sensor response was observed to be completely reversible in nature with a response time of 120 seconds. The system was further demonstrated to respond similarly using near-infrared dyes (Alexa Fluor-647-labeled dextran as donor and QSY-21-conjugated apo-GOx as acceptor) which exhibited a sensitivity of 0.94%/mM glucose with a linear response in range of 0-50mM glucose, making the sensor more amenable to in vivo use, when implanted in scattering tissue.

引用

页码：4098 / +

页数：2

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