Advantages of Peptide Nucleic Acids as Diagnostic Platforms for Detection of Nucleic Acids in Resource-Limited Settings

被引：28

作者：

Zhang, Ning ^{[1
]}

Appella, Daniel H. ^{[1
]}

机构：

[1] NIDDKD, Bioorgan Chem Lab, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷

基金：

美国国家卫生研究院;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; PNA MOLECULAR BEACONS; REAL-TIME PCR; LUNG-CANCER; DNA; HYBRIDIZATION; BACKBONE; THERAPY; ASSAY;

D O I：

10.1086/650389

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Peptide nucleic acids are a class of nondegradable oligonucleotide mimics that can be used as probes for nucleic acid sequences and could convey the necessary stability to be a diagnostic tool for use in a resource-limited setting. In this review, there is a brief introduction to the field of peptide nucleic acids and their potential benefits as probes for DNA and RNA sequences, followed by highlights of ways by which peptide nucleic acids could benefit a number of established diagnostic tools for human immunodeficiency virus detection.

引用

页码：S42 / S45

页数：4

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