γ-substituted peptide nucleic acids constructed from L-lysine are a versatile scaffold for multifunctional display

被引：90

作者：

Englund, Ethan A.

Appella, Daniel H. ^{[1
]}

机构：

[1] NIDDK, Bioorgan Chem Lab, NIH, DHHS, Bethesda, MD 20892 USA

[2] NIDDK, NIH, DHHS, Bethesda, MD 20892 USA

[3] Northwestern Univ, Evanston, IL 60208 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 09期

关键词：

binding studies; chiral backbone; DNA structures; nucleic acids; peptide nucleic acids;

D O I：

10.1002/anie.200603483

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) On display: This model shows DNA (pink) annealed to a peptide nucleic acid (PNA; orange) containing several L-lysine γ side chains (LKγ-PNA) in the middle of the PNA oligomer. The LKγ-PNA side chains project away from the nucleobase pairs (purple) and line the periphery of the duplex. This strategy can be used for the multifunctional display of various functional groups from the PNA residues without diminishing the binding affinity or selectivity to DNA. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：1414 / 1418

页数：5

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