Determination of anti-inflammatory drugs and estrogens in water by HPLC with UV detection

被引：113

作者：

Stafiej, Anna

Pyrzynska, Krystyna

Regan, Fiona

机构：

[1] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland

[2] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

来源：

JOURNAL OF SEPARATION SCIENCE | 2007年 / 30卷 / 07期

关键词：

acidic drugs; estrogens; water analysis;

D O I：

10.1002/jssc.200600433

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An analytical method based on LC and UV detection has been developed for the determination of anti-inflammatory compounds and estrogens in water samples. The drugs investigated were diclofenac, ketoprofen, ibuprofen, naproxen, clofibric acid, estriol, 17 beta-estradiol, estrone and ethynylestradiol. The detection limits were in the range of 6-74 mu g/L and 0.041-0.16 mg/L for acidic pharmaceuticals and estrogens, respectively, using narrow-bore C18 analytical column. Analyte enrichment from water samples was achieved by SPE procedure using polymeric Strata-X cartridges. Average recoveries obtained from 2.5 L of surface water sample were in the range of 77-98%.

引用

收藏

页码：985 / 991

页数：7

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