Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective IKs-blocking Class III antiarrhythmic agents

被引：15

作者：

Butcher, JW ^{[1
]}

Liverton, NJ

Claremon, DA

Freidinger, RM

Jurkiewicz, NK

Lynch, JJ

Salata, JJ

Wang, JX

Dieckhaus, CM

Slaughter, DE

Vyas, K

机构：

[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA

[2] Merck Res Labs, Dept Pharmacol, W Point, PA 19486 USA

[3] Merck Res Labs, Dept Drug Metab, W Point, PA 19486 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(03)00049-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones having various N-1 substituents were identified as potent and selective blockers of the slowly activating cardiac delayed rectifier potassium current (I-Ks). Compound 11 is the most potent I-Ks channel blocker reported to date. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1165 / 1168

页数：4

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