Stereoselective synthesis of L-733,060

被引：49

作者：

Bhaskar, G ^{[1
]}

Rao, BV ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ 3, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(02)02772-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective synthesis of non-peptidic neurokinin NK1 receptor antagonist L-733,060 is described using ring-closing metathesis as a key step, starting from L-phenylglycine. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：915 / 917

页数：3

共 22 条

[11] Recent advances in olefin metathesis and its application in organic synthesis [J].

Grubbs, RH ;

Chang, S .

TETRAHEDRON, 1998, 54 (18) :4413-4450

[12] PIPERIDINE-ETHER BASED HNK(1) ANTAGONISTS .1. DETERMINATION OF THE RELATIVE AND ABSOLUTE STEREOCHEMICAL REQUIREMENTS [J].

HARRISON, T ;

WILLIAMS, BJ ;

SWAIN, CJ ;

BALL, RG .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (21) :2545-2550

[13] Asymmetric synthesis of (2S,3S)-3-hydroxy-2-phenylpiperidine via ring expansion [J].

Lee, J ;

Hoang, T ;

Lewis, S ;

Weissman, SA ;

Askin, D ;

Volante, RP ;

Reider, PJ .

TETRAHEDRON LETTERS, 2001, 42 (36) :6223-6225

[14] SUBSTANCE-P ACTIVATION OF RHEUMATOID SYNOVIOCYTES - NEURAL PATHWAY IN PATHOGENESIS OF ARTHRITIS [J].

LOTZ, M ;

CARSON, DA ;

VAUGHAN, JH .

SCIENCE, 1987, 235 (4791) :893-895

[15] EFFECT OF NEUROPEPTIDES ON PRODUCTION OF INFLAMMATORY CYTOKINES BY HUMAN-MONOCYTES [J].

LOTZ, M ;

VAUGHAN, JH ;

CARSON, DA .

SCIENCE, 1988, 241 (4870) :1218-1221

[16] NEUROGENIC VERSUS VASCULAR MECHANISMS OF SUMATRIPTAN AND ERGOT ALKALOIDS IN MIGRAINE [J].

MOSKOWITZ, MA .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (08) :307-311

[17] EFFECT OF A TACHYKININ ANTAGONIST ON A NOCICEPTIVE REFLEX IN THE ISOLATED SPINAL-CORD TAIL PREPARATION OF THE NEWBORN RAT [J].

OTSUKA, M ;

YANAGISAWA, M .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 395 :255-270

[18] SUBSTANCE-P PRIMES HUMAN NEUTROPHIL ACTIVATION - A MECHANISM FOR NEUROLOGICAL REGULATION OF INFLAMMATION [J].

PERIANIN, A ;

SNYDERMAN, R ;

MALFROY, B .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 161 (02) :520-524

[19]

Pernerstorfer J, 1999, SYNTHESIS-STUTTGART, P138

[20] Highly enantioselective synthesis of 3-hydroxy-2-phenylpiperidine via the sharpless AD-reaction [J].

Stadler, H ;

Bös, M .

HETEROCYCLES, 1999, 51 (05) :1067-1071

← 1 2 3 →