Microengineering of cellular interactions

被引：474

作者：

Folch, A ^{[1
]}

Toner, M

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Engn Med, Boston, MA 02114 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Surg Serv, Boston, MA 02114 USA

[4] Shriners Burns Hosp, Boston, MA 02114 USA

来源：

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING | 2000年 / 2卷

关键词：

cellular patterns; micropatterning; cell-cell interactions; cellular microdevices; lithography;

D O I：

10.1146/annurev.bioeng.2.1.227

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Tissue function is modulated by an intricate architecture of cells and biomolecules on a micrometer scale. Until now, in vitro cellular interactions were mainly studied by random seeding over homogeneous substrates. Although this strategy has led to important discoveries, it is clearly a nonoptimal analog of the in vivo scenario. With the incorporation-and adaptation-of microfabrication technology into biology, it is now possible to design surfaces that reproduce some of the aspects of that architecture. This article reviews past research on the engineering of cell-substrate, cell-cell, and cell-medium interactions on the micrometer scale.

引用

页码：227 / +

页数：37

共 219 条

[81] Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates [J].