Single-triggered trimeric prodrugs

被引:128
作者
Haba, K
Popkov, M
Shamis, M
Lerner, RA
Barbas, CF
Shabat, D [1 ]
机构
[1] Tel Aviv Univ, Sch Chem, Fac Exact Sci, Dept Organ Chem, IL-69978 Tel Aviv, Israel
[2] Scripps Res Inst, Skaggs Inst Chem Biol, Dept Biol Mol, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Skaggs Inst Chem Biol, Dept Chem, La Jolla, CA 92037 USA
关键词
adol reaction; catalytic antibodies; dendrimers; drug delivery; prodrugs;
D O I
10.1002/anie.200461657
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The knock-on effect of a single catalytic reaction by a specific enzyme on a prodrug platform initiates the sequential collapse of the whole array to release the active drug units (see scheme). Such a dendritic system may provide a means to improve selective chemotherapeutic approaches in cancer therapy.
引用
收藏
页码:716 / 720
页数:5
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