Asymmetric synthesis of diarylmethyl amines by rhodium-catalyzed asymmetric addition of aryl titanium reagents to imines

被引：106

作者：

Hayashi, T ^{[1
]}

Kawai, M ^{[1
]}

Tokunaga, N ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 45期

关键词：

amines; arylation; asymmetric catalysis; rhodium; titanium;

D O I：

10.1002/anie.200461338

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rational tuning of the arene sulfonamide moiety (by introducing isopropyl groups onto the phenyl ring) brought about high enantioselectivity in the asymmetric synthesis of diarylmethyl amines by the title reaction (see scheme). Ar1 = 4-CF3C6H4, 4-ClC 6H4, 4-FC6H4, 3-MeOC 6H4, 4-MeOC6H4, 2-MeC 6H4, 1-naphthyl, Ph; Ar2 = Ph, 4-FC 6H4, 3-MeOC6H4, 4-MeOC 6H4.

引用

页码：6125 / 6128

页数：4

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