Distance-based microfluidic quantitative detection methods for point-of-care testing

被引:149
作者
Tian, Tian [1 ]
Li, Jiuxing [1 ]
Song, Yanling [1 ]
Zhou, Leiji [1 ]
Zhu, Zhi [1 ]
Yang, Chaoyong James [1 ]
机构
[1] Xiamen Univ, MOE Key Lab Spectrochem Anal & Instrumentat, Collaborat Innovat Ctr Chem Energy Mat,Coll Chem, Key Lab Chem Biol Fujian Prov,State Key Lab Phys, Xiamen 361005, Peoples R China
基金
美国国家科学基金会;
关键词
BAR-CHART CHIP; CROSS-LINKED HYDROGEL; LATERAL-FLOW ASSAY; ANALYTICAL DEVICE; COLORIMETRIC DETECTION; TEAR LACTOFERRIN; LABEL-FREE; LOW-COST; PAPER; PLATFORM;
D O I
10.1039/c5lc01562f
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Equipment-free devices with quantitative readout are of great significance to point-of-care testing (POCT), which provides real-time readout to users and is especially important in low-resource settings. Among various equipment-free approaches, distance-based visual quantitative detection methods rely on reading the visual signal length for corresponding target concentrations, thus eliminating the need for sophisticated instruments. The distance-based methods are low-cost, user-friendly and can be integrated into portable analytical devices. Moreover, such methods enable quantitative detection of various targets by the naked eye. In this review, we first introduce the concept and history of distance-based visual quantitative detection methods. Then, we summarize the main methods for translation of molecular signals to distance-based readout and discuss different microfluidic platforms (glass, PDMS, paper and thread) in terms of applications in biomedical diagnostics, food safety monitoring, and environmental analysis. Finally, the potential and future perspectives are discussed.
引用
收藏
页码:1139 / 1151
页数:13
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