Chloramphenicol and expression of multidrug efflux pump in Enterobacter aerogenes

被引：63

作者：

Ghisalberti, D ^{[1
]}

Masi, M ^{[1
]}

Pagès, JM ^{[1
]}

Chevalier, J ^{[1
]}

机构：

[1] Univ Mediterranee, Fac Med, IFR48, EA2197, F-13385 Marseille 05, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 328卷 / 04期

关键词：

efflux pump; Enterobacter aerogenes; chloramphenicol; efflux pump inhibitor; multidrug resistance;

D O I：

10.1016/j.bbrc.2005.01.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chloramphenicol has been reported to act as an inducer of the multidrug resistance in Escherichia coli. A resistant variant able to grow on plates containing 64 mug/ml chloramphenicol was obtained from the Enterobacter aerogenes ATCC 13048-type strain. Chloramphenicol resistance was due to an active efflux of this antibiotic and it was associated with resistance to fluoroquinolones and tetracycline, but not to aminoglycoside or beta-lactam antibiotics. MDR in the chloramphenicol-resistant variant is linked to the overexpression of the major AcrAB-TolC efflux system. This overexpression seems unrelated to the global Mar and the local AcrR regulatory pathways. (C) 2005 Published by Elsevier Inc.

引用

页码：1113 / 1118

页数：6

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