Pathway Palette: A rich internet application for peptide-, protein- and network-oriented analysis of MS data

被引：15

作者：

Askenazi, Manor ^{[1
,2
,3
,4
]}

Li, Shaojuan ^{[1
,2
]}

Singh, Saurav ^{[1
,2
]}

Marto, Jarrod A. ^{[1
,2
,3
]}

机构：

[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Blais Prote Ctr, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[4] Hebrew Univ Jerusalem, Dept Biol Chem, Jerusalem, Israel

来源：

PROTEOMICS | 2010年 / 10卷 / 09期

关键词：

Bioinformatics; Mass Spectrometry proteomics; Network analysis; Protein-protein interaction; Quantitative proteomics; Rich internet application; GENE ONTOLOGY;

D O I：

10.1002/pmic.200900723

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent improvements in proteomic technologies have collectively yielded data sets that far exceed the capabilities of typical low-throughput interpretation strategies. Unfortunately, tools designed to leverage the "peptide-centric" content of MS-based proteomics lag the current rate of data production. Here, we describe Pathway Palette (http://blaispathways.dfci.harvard.edu), a freely accessible internet application that enables researchers to easily transition from peptides to biological pathways, while simultaneously retaining the qualitative and quantitative aspects of the underlying MS data.

引用

页码：1880 / 1885

页数：6

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