The transcription cycle in vivo: A blind watchmaker at work

被引：14

作者：

Vermeulen, W

Houtsmuller, AB

机构：

[1] Erasmus MC Rotterdam, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus MC Rotterdam, Dept Pathol, NL-3000 DR Rotterdam, Netherlands

来源：

MOLECULAR CELL | 2002年 / 10卷 / 06期

关键词：

D O I：

10.1016/S1097-2765(02)00795-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent work by the Cook and Misteli laboratories addresses the issue of assembly and action of the transcription machinery. Live cell studies of RNA polymerases I (RNAP1) and II (RNAP2) indicate that transcription complexes are assembled in a stochastic fashion from freely diffusible subunits. This contrasts to models involving stable holo-complexes.

引用

收藏

页码：1264 / 1266

页数：3

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