Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies

被引：36

作者：

Amblard, F

Nolan, SP

Schinazi, RF

Agrofoglio, LA

机构：

[1] CNRS, UMR 6005, ICOA, F-45067 Orleans 2, France

[2] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

[3] Emory Univ, Vet Affairs Med Ctr, Atlanta, GA 30033 USA

[4] Emory Univ, Biochem Pharmacol Lab, Atlanta, GA 30033 USA

来源：

TETRAHEDRON | 2005年 / 61卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.tet.2004.11.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel acyclonucleosides (9a-d, 10a-d, 18a,b and 19a,b) have been prepared using Pd(0) and cross-metathesis methodologies. The allylic N-alkylation under Tsuji-Trost conditions was used to introduce the nucleobase, while the Suzuki-Miyaura reaction afforded C-5 substituted uracil analogues. The cross-metathesis performed with a ruthenium catalyst was used to provide new acycloalkenyl nucleosides. The antiviral activities of all final compounds have been evaluated. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：537 / 544

页数：8

共 54 条

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