Metabolic Mediators of the Association Between Adult Weight Gain and Colorectal Cancer: Data From the European Prospective Investigation Into Cancer and Nutrition (EPIC) Cohort

被引：24

作者：

Aleksandrova, Krasimira ^{[1
]}

Schlesinger, Sabrina ^{[2
]}

Fedirko, Veronika ^{[3
,4
]}

Jenab, Mazda ^{[5
]}

Bueno-de-Mesquita, Bas ^{[6
,7
,8
,9
]}

Freisling, Heinz ^{[5
]}

Romieu, Isabelle ^{[5
]}

Pischon, Tobias ^{[10
]}

Kaaks, Rudolf ^{[11
]}

Gunter, Marc J. ^{[6
]}

Dahm, Christina C. ^{[12
]}

Overvad, Kim ^{[12
]}

Rostgaard-Hansen, Agnetha Linn ^{[13
]}

Tjonneland, Anne ^{[13
]}

Trichopoulou, Antonia ^{[14
,15
]}

Bamia, Christina ^{[14
,15
]}

Lagiou, Pagona ^{[14
,16
,17
]}

Agnoli, Claudia ^{[18
]}

Mattiello, Amalia ^{[19
]}

Bradbury, Kathryn ^{[20
]}

Khaw, Kay-Tee ^{[21
]}

Riboli, Elio ^{[6
]}

Boeing, Heiner ^{[22
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Nutr Immun & Metab Start Up Lab, Dept Epidemiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany

[2] Christian Albrechts Univ Kiel, Inst Epidemiol, Kiel, Germany

[3] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

[4] Emory Univ, Winship Canc Ctr, Atlanta, GA 30322 USA

[5] Int Agcy Res Canc, Lyon, France

[6] Imperial Coll London, Publ Hlth & Primary Care, Div Epidemiol, London, England

[7] Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands

[8] Univ Med Ctr Utrecht, Dept Gastroenterol Hepatol, Utrecht, Netherlands

[9] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[10] Max Delbrueck Ctr Mol Med, Mol Epidemiol Grp, Berlin, Germany

[11] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[12] Aarhus Univ, Dept Publ Hlth, Sect Epidemiol, Aarhus, Denmark

[13] Danish Canc Soc Res Ctr, Diet Genes & Environm Unit, Copenhagen, Denmark

[14] Univ Athens, Sch Med, WHO Collaborat Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, Athens, Greece

[15] Hellen Hlth Fdn, Athens, Greece

[16] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[17] Acad Athens, Bur Epidemiol Res, Athens, Greece

[18] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[19] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[20] Univ Oxford, Med Sci Div, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England

[21] Univ Cambridge, Cambridge Inst Publ Hlth, Sch Clin Med, Dept Publ Hlth & Primary Care, Cambridge, England

[22] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2017年 / 185卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

adiposity; adult weight gain; colorectal cancer; metabolic mediators; SOLUBLE LEPTIN RECEPTOR; C-REACTIVE PROTEIN; OXIDATIVE STRESS; VITAMIN-D; RISK; METAANALYSIS; COLON; IRON; INFLAMMATION; POPULATIONS;

D O I：

10.1093/aje/kww194

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort. The proportions of mediated effects (%) were estimated on the basis of differences in percent effect changes in conditional logistic regression models with and without additional adjustment for individual biomarkers. Greater adult weight gain (>= 300 g/year vs. <300 g/year) was associated with a higher risk of colon cancer (multivariable adjusted relative risk = 1.54, 95% confidence interval: 1.07, 2.24) but not rectal cancer (relative risk = 1.07, 95% confidence interval: 0.68, 1.66). This association was accounted for mostly by attained waist circumference (reduction of 61%) and by the biomarkers soluble leptin receptor (reduction of 43%) and glycated hemoglobin (reduction of 28%). These novel data suggest that the observed association between adult weight gain and colon cancer could be primarily explained by attained abdominal fatness and biomarkers of metabolic dysfunction.

引用

页码：751 / 764

页数：14

共 48 条

[1]

Reliability of biomarkers of iron status, blood lipids, oxidative stress, vitamin D, C-reactive protein and fructosamine in two Dutch cohorts [J].

Al-Delaimy, W. K. ;

Jansen, E. H. J. M. ;

Peeters, P. H. M. ;

Van der Laan, J. D. ;

Van Noord, P. A. H. ;

Boshuizen, H. C. ;

Van der Schouw, Y. T. ;

Jenab, M. ;

Ferrari, P. ;

Beuno-De-Mesquita, H. B. .

BIOMARKERS, 2006, 11 (04) :370-382

[2]

Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) [J].

Aleksandrova, Krasimira ;

Jenab, Mazda ;

Bueno-de-Mesquita, H. Bas ;

Fedirko, Veronika ;

Kaaks, Rudolf ;

Lukanova, Annekatrin ;

van Duijnhoven, Franzel J. B. ;

Jansen, Eugene ;

Rinaldi, Sabina ;

Romieu, Isabelle ;

Ferrari, Pietro ;

Murphy, Neil ;

Gunter, Marc J. ;

Riboli, Elio ;

Westhpal, Sabine ;

Overvad, Kim ;

Tjonneland, Anne ;

Halkjaer, Jytte ;

Boutron-Ruault, Marie-Christine ;

Dossus, Laure ;

Racine, Antoine ;

Trichopoulou, Antonia ;

Bamia, Christina ;

Orfanos, Philippos ;

Agnoli, Claudia ;

Palli, Domenico ;

Panico, Salvatore ;

Tumino, Rosario ;

Vineis, Paolo ;

Peeters, Petra H. ;

Duell, Eric J. ;

Molina-Montes, Esther ;

Ramon Quiros, J. ;

Dorronsoro, Miren ;

Chirlaque, Maria-Dolores ;

Barricarte, Aurelio ;

Ljuslinder, Ingrid ;

Palmqvist, Richard ;

Travis, Ruth C. ;

Khaw, Kay-Tee ;

Wareham, Nicholas ;

Pischon, Tobias ;

Boeing, Heiner .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2014, 29 (04) :261-275

[3]

Adiposity, mediating biomarkers and risk of colon cancer in the European Prospective Investigation into Cancer and Nutrition Study [J].

Aleksandrova, Krasimira ;

Drogan, Dagmar ;

Boeing, Heiner ;

Jenab, Mazda ;

Bueno-de-Mesquita, H. Bas ;

Jansen, Eugene ;

van Duijnhoven, Fraenzel J. B. ;

Rinaldi, Sabina ;

Fedirko, Veronika ;

Romieu, Isabelle ;

Kaaks, Rudolf ;

Riboli, Elio ;

Gunter, Marc J. ;

Romaguera, Dora ;

Westhpal, Sabine ;

Overvad, Kim ;

Tjonneland, Anne ;

Halkjaer, Jytte ;

Boutron-Ruault, Marie-Christine ;

Clavel-Chapelon, Francoise ;

Lukanova, Annekatrin ;

Trichopoulou, Antonia ;

Trichopoulos, Dimitrios ;

Vidalis, Pavlos ;

Panico, Salvatore ;

Agnoli, Claudia ;

Palli, Domenico ;

Tumino, Rosario ;

Vineis, Paolo ;

Buckland, Genevieve ;

Sanchez-Cruz, Jose-Juan ;

Dorronsoro, Miren ;

Tormo Diaz, Maria Jose ;

Barricarte, Aurelio ;

Ramon Quiros, J. ;

Peeters, Petra H. ;

May, Anne M. ;

Hallmans, Goran ;

Palmqvist, Richard ;

Crowe, Francesca L. ;

Khaw, Kay-Tee ;

Wareham, Nickolas ;

Pischon, Tobias .

INTERNATIONAL JOURNAL OF CANCER, 2014, 134 (03) :612-621

[4]

Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition [J].

Aleksandrova, Krasimira ;

Pischon, Tobias ;

Buijsse, Brian ;

May, Anne M. ;

Peeters, Petra H. ;

Bueno-de-Mesquita, H. Bas ;

Jenab, Mazda ;

Fedirko, Veronika ;

Dahm, Christina C. ;

Siersema, Peter D. ;

Freisling, Heinz ;

Ferrari, Pietro ;

Overvad, Kim ;

Tjonneland, Anne ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Naska, Androniki ;

Pala, Valeria ;

Mattiello, Amalia ;

Ohlsson, Bodil ;

Jirstrom, Karin ;

Key, Timothy J. ;

Khaw, Kay-Tee ;

Riboli, Elio ;

Boeing, Heiner .

EUROPEAN JOURNAL OF CANCER, 2013, 49 (16) :3526-3536

[5]

Aleksandrova Krasimira, 2013, Curr Nutr Rep, V2, P1

[6]

Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort [J].

Aleksandrova, Krasimira ;

Boeing, Heiner ;

Jenab, Mazda ;

Bueno-de-Mesquita, H. Bas ;

Jansen, Eugene ;

van Duijnhoven, Franzel J. B. ;

Rinaldi, Sabina ;

Fedirko, Veronika ;

Romieu, Isabelle ;

Riboli, Elio ;

Gunter, Marc J. ;

Westphal, Sabine ;

Overvad, Kim ;

Tjonneland, Anne ;

Halkjaer, Jytte ;

Racine, Antoine ;

Boutron-Ruault, Marie-Christine ;

Clavel-Chapelon, Francoise ;

Kaaks, Rudolf ;

Lukanova, Annekatrin ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

Mattiello, Amalia ;

Pala, Valeria ;

Palli, Domenico ;

Tumino, Rosario ;

Vineis, Paolo ;

Buckland, Genevieve ;

Sanchez, Maria-Jose ;

Amiano, Pilar ;

Maria Huerta, Jose ;

Barricarte, Aurelio ;

Menendez, Virginia ;

Peeters, Petra H. ;

Soderberg, Stefan ;

Palmqvist, Richard ;

Allen, Naomi E. ;

Crowe, Francesca L. ;

Khaw, Kay-Tee ;

Wareham, Nickolas ;

Pischon, Tobias .

CANCER RESEARCH, 2012, 72 (20) :5328-5337

[7]

Total and high-molecular weight adiponectin and risk of colorectal cancer: the European Prospective Investigation into Cancer and Nutrition Study [J].

Aleksandrova, Krasimira ;

Boeing, Heiner ;

Jenab, Mazda ;

Bueno-de-Mesquita, H. Bas ;

Jansen, Eugene ;

van Duijnhoven, Franzel J. B. ;

Fedirko, Veronika ;

Rinaldi, Sabina ;

Romieu, Isabelle ;

Riboli, Elio ;

Romaguera, Dora ;

Westphal, Sabine ;

Overvad, Kim ;

Tjonneland, Anne ;

Boutron-Ruault, Marie Christine ;

Clavel-Chapelon, Francoise ;

Kaaks, Rudolf ;

Lukanova, Annekatrin ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

Agnoli, Claudia ;

Mattiello, Amalia ;

Saieva, Calogero ;

Vineis, Paolo ;

Tumino, Rosario ;

Peeters, Petra H. ;

Argueelles, Marcial ;

Bonet, Catalina ;

Sanchez, Maria-Jose ;

Dorronsoro, Miren ;

Huerta, Jose-Maria ;

Barricarte, Aurelio ;

Palmqvist, Richard ;

Hallmans, Goran ;

Khaw, Kay-Tee ;

Wareham, Nick ;

Allen, Naomi E. ;

Crowe, Francesca L. ;

Pischon, Tobias .

CARCINOGENESIS, 2012, 33 (06) :1211-1218

[8]

Circulating C-Reactive Protein Concentrations and Risks of Colon and Rectal Cancer: A Nested Case-Control Study Within the European Prospective Investigation into Cancer and Nutrition [J].

Aleksandrova, Krasimira ;

Jenab, Mazda ;

Boeing, Heiner ;

Jansen, Eugene ;

Bueno-de-Mesquita, H. Bas ;

Rinaldi, Sabina ;

Riboli, Elio ;

Overvad, Kim ;

Dahm, Christina C. ;

Olsen, Anja ;

Tjonneland, Anne ;

Boutron-Ruault, Marie-Christine ;

Clavel-Chapelon, Francoise ;

Morois, Sophie ;

Palli, Domenico ;

Krogh, Vittorio ;

Tumino, Rosario ;

Vineis, Paolo ;

Panico, Salvatore ;

Kaaks, Rudolf ;

Rohrmann, Sabine ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

van Duijnhoven, Fraenzel J. B. ;

Leufkens, Anke M. ;

Peeters, Petra H. ;

Rodriguez, Laudina ;

Bonet, Catalina ;

Sanchez, Maria-Jose ;

Dorronsoro, Miren ;

Navarro, Carmen ;

Barricarte, Aurelio ;

Palmqvist, Richard ;

Hallmans, Goran ;

Khaw, Kay-Tee ;

Wareham, Nicholas ;

Allen, Naomi E. ;

Spencer, Elizabeth ;

Romaguera, Dora ;

Norat, Teresa ;

Pischon, Tobias .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2010, 172 (04) :407-418

[9]

THE MODERATOR MEDIATOR VARIABLE DISTINCTION IN SOCIAL PSYCHOLOGICAL-RESEARCH - CONCEPTUAL, STRATEGIC, AND STATISTICAL CONSIDERATIONS [J].

BARON, RM ;

KENNY, DA .

JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY, 1986, 51 (06) :1173-1182

[10]

Diet and cancer - The European prospective investigation into cancer and nutrition [J].

Bingham, S ;

Riboli, E .

NATURE REVIEWS CANCER, 2004, 4 (03) :206-215

← 1 2 3 4 5 →