Vibrio cholerae strains with mutations in an atypical type I secretion system accumulate RTX toxin intracellularly

被引：54

作者：

Boardman, BK ^{[1
]}

Satchell, KJF ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

来源：

JOURNAL OF BACTERIOLOGY | 2004年 / 186卷 / 23期

关键词：

D O I：

10.1128/JB.186.23.8137-8143.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study shows that the Vibrio cholerae RTX toxin is secreted by a four-component type I secretion system (TISS) encoded by rtxB, rtxD, rtxE, and WC. ATP-binding site mutations in both RtxB and RtxE blocked secretion, demonstrating that this atypical TISS requires two transport ATPases that may function as a heterodimer.

引用

页码：8137 / 8143

页数：7

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