Cytotoxic Activity of 6-alkynyl- and 6-alkenylpurines

被引：31

作者：

Bråthe, A

Gundersen, LL

Nisson-Meyer, J

Rise, F

Spilsberg, B

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

[2] Univ Oslo, Dept Biochem, N-0316 Oslo, Norway

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(03)00011-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6-Alkynyl- and 6-alkenylpurines have been screened for cytotoxic activity against a human chronic myelogenous leukemia cell line; K-562 cells using a [H-3]-thymidine incorporation assay. Most alkynes displayed cytotoxicity comparable to, or better than, the known anticancer drugs 6-mercaptopurine and fludarabine. The 6-alkenylpurines, which are promising plant growth stimulators and 15-lipoxygenase inhibitors, exhibited only low toxicity. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：877 / 880

页数：4

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