The hormonal control of food intake

被引:441
作者
Coll, Anthony P. [1 ]
Farooqi, I. Sadaf [1 ]
O'Rahilly, Stephen [1 ]
机构
[1] Addenbrookes Hosp, Cambridge Inst Med Res, Dept Clin Biochem, Cambridge CB2 2XY, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1016/j.cell.2007.04.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Numerous circulating peptides and steroids produced in the body influence appetite through their actions on the hypothalamus, the brain stem, and the autonomic nervous system. These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas. In this Review we provide a synthesis of recent evidence concerning the actions of these hormones on food intake.
引用
收藏
页码:251 / 262
页数:12
相关论文
共 89 条
  • [61] Effects of obestatin on energy balance and growth hormone secretion in rodents
    Nogueiras, Ruben
    Pfluger, Paul
    Tovar, Sulay
    Arnold, Myrtha
    Mitchell, Sharon
    Morris, Amanda
    Perez-Tilve, Diego
    Vazquez, Maria J.
    Wiedmer, Petra
    Castaneda, Tamara R.
    DiMarchi, Richard
    Tschop, Matthias
    Schurmann, Annette
    Joost, Hans-Georg
    Williams, Lynda M.
    Langhans, Wolfgang
    Dieguez, Carlos
    [J]. ENDOCRINOLOGY, 2007, 148 (01) : 21 - 26
  • [62] Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    Obici, S
    Feng, ZH
    Karkanias, G
    Baskin, DG
    Rossetti, L
    [J]. NATURE NEUROSCIENCE, 2002, 5 (06) : 566 - 572
  • [63] Leptin-replacement therapy for lipodystrophy
    Oral, EA
    Simha, V
    Ruiz, E
    Andewelt, A
    Premkumar, A
    Snell, P
    Wagner, AJ
    DePaoli, AM
    Reitman, ML
    Taylor, SI
    Gorden, P
    Garg, A
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (08) : 570 - 578
  • [64] Rapid rewiring of arcuate nucleus feeding circuits by leptin
    Pinto, S
    Roseberry, AG
    Liu, HY
    Diano, S
    Shanabrough, M
    Cai, XL
    Friedman, JM
    Horvath, TL
    [J]. SCIENCE, 2004, 304 (5667) : 110 - 115
  • [65] Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
    Plum, Leona
    Ma, Xiaosong
    Hampel, Brigitte
    Balthasar, Nina
    Coppari, Roberto
    Muenzberg, Heike
    Shanabrough, Marya
    Burdakov, Denis
    Rother, Eva
    Janoschek, Ruth
    Alber, Jens
    Belgardt, Bengt F.
    Koch, Linda
    Seibler, Jost
    Schwenk, Frieder
    Fekete, Csaba
    Suzuki, Akira
    Mak, Tak W.
    Krone, Wilhelm
    Horvath, Tamas L.
    Ashcroft, Frances M.
    Bruening, Jens C.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) : 1886 - 1901
  • [66] Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms
    Ricci, MR
    Lee, MJ
    Russell, CD
    Wang, YX
    Sullivan, S
    Schneider, SH
    Brolin, RE
    Fried, SK
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2005, 288 (04): : E798 - E804
  • [67] Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    Rios, M
    Fan, GP
    Fekete, C
    Kelly, J
    Bates, B
    Kuehn, R
    Lechan, RM
    Jaenisch, R
    [J]. MOLECULAR ENDOCRINOLOGY, 2001, 15 (10) : 1748 - 1757
  • [68] Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    Sakurai, T
    Amemiya, A
    Ishii, M
    Matsuzaki, I
    Chemelli, RM
    Tanaka, H
    Williams, SC
    Richardson, JA
    Kozlowski, GP
    Wilson, S
    Arch, JRS
    Buckingham, RE
    Haynes, AC
    Carr, SA
    Annan, RS
    McNulty, DE
    Liu, WS
    Terrett, JA
    Elshourbagy, NA
    Bergsma, DJ
    Yanagisawa, M
    [J]. CELL, 1998, 92 (04) : 573 - 585
  • [69] Hypothalamic regulation of sleep and circadian rhythms
    Saper, CB
    Scammell, TE
    Lu, J
    [J]. NATURE, 2005, 437 (7063) : 1257 - 1263
  • [70] INSULIN IN THE BRAIN - A HORMONAL REGULATOR OF ENERGY-BALANCE
    SCHWARTZ, MW
    FIGLEWICZ, DP
    BASKIN, DG
    WOODS, SC
    PORTE, D
    [J]. ENDOCRINE REVIEWS, 1992, 13 (03) : 387 - 414