Specific C-C bond construction by remote C-H activation: Synthesis of (-)-trans-cembranolide

被引：35

作者：

Taber, DF

Song, Y

机构：

[1] Department of Chemistry, University of Delaware, Newark

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 19期

关键词：

D O I：

10.1021/jo971065w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of (-)-trans-cembranolide (1), isolated from Sinularia mayi Luttschw., is described. The key step in the synthesis is the diastereoselective Rh-mediated cyclization of the enantiomerically pure diazo ester 4 to the tetrahydrofuran 3a.

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页码：6603 / 6607

页数：5

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