Distance dependency of exciton coupled circular dichroism using turn and helical peptide spacers

被引：17

作者：

Oancea, S

Formaggio, F

Campestrini, S

Broxterman, QB

Kaptein, B

Toniolo, C ^{[1
]}

机构：

[1] Univ Padua, Inst Biomol Chem, CNR, Dept Organ Chem, I-35131 Padua, Italy

[2] Univ Padua, Inst Membrane Technol, CNR, Dept Organ Chem, I-35131 Padua, Italy

[3] DSM Pharmaceut Prod, NL-6160 MD Geleen, Netherlands

来源：

BIOPOLYMERS | 2003年 / 72卷 / 02期

关键词：

circular dichroism; exciton coupling; 3(10)-helix; peptides; porphyrin; spacers;

D O I：

10.1002/bip.10315

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Porphyrins are promising chromophores for the investigation of. the. still unexplored area of 3-dimensional structural studies of proteins by using the exciton coupled circular dichroism (CD) method. The synthesis, conformational. characterization by FTIR absorption and H-1-NMR, and CD properties are described for a model bis-porphyrin system based on homooligo-[L-(alphaMe)Val](n) peptides as rigid spacers. In particular, the coupled CD phenomenon is experimentally detected, the intensity of which is modulated by the interchromophoric distance. These results extend and integrate those already reported with steroid, dimeric steroid, and brevetoxin bridges. (C) 2003 Wiley Periodicals, Inc.

引用

页码：105 / 115

页数：11

共 53 条

[41]

SONKE T, 1999, STEREOSELECTIVE BIOC, P23

[42] INTRAMOLECULAR INTERACTION OF PORPHYRIN MOIETIES IN 2,5-PIPERAZINEDIONE-BRIDGED PORPHYRIN DIMERS [J].