General Anesthetic Actions on GABAA Receptors

被引：194

作者：

Garcia, Paul S.

Kolesky, Scott E.

Jenkins, Andrew ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Rollins Res Ctr, Dept Anesthesiol, Atlanta, GA 30322 USA

来源：

CURRENT NEUROPHARMACOLOGY | 2010年 / 8卷 / 01期

关键词：

GABA(A) Receptor; General Anesthetic; Isoflurane; Desflurane; Sevoflurane; Propofol; Etomidate; Barbiturates; ACID TYPE-A; INHIBITORY POSTSYNAPTIC CURRENTS; SUBUNIT MESSENGER-RNAS; GATED ION CHANNELS; VOLATILE ANESTHETICS; HIPPOCAMPAL-NEURONS; INHALED ANESTHETICS; GLYCINE RECEPTORS; OPTICAL ISOMERS; ALPHA-1; SUBUNIT;

D O I：

10.2174/157015910790909502

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor. In this review we will discuss what is known about anesthetic - GABA(A) receptor interactions.

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页码：2 / 9

页数：8

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共 73 条

[1] Consciousness and Anesthesia [J].

Alkire, Michael T. ;

Hudetz, Anthony G. ;

Tononi, Giulio .

SCIENCE, 2008, 322 (5903) :876-880

[2] Neural mechanisms of anaesthesia [J].

Antkowiak, B ;

Kirschfeld, K .

ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE, 2000, 35 (12) :731-743

[3] Macroscopic sites of anesthetic action: brain versus spinal cord [J].

Antognini, JF ;

Carstens, E .

TOXICOLOGY LETTERS, 1998, 101 :51-58

[4] Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by γ-aminobutyric acidA receptors in hippocampal neurons [J].

Bai, DL ;

Zhu, GY ;

Pennefather, P ;

Jackson, MF ;

Macdonald, JF ;

Orser, BA .

MOLECULAR PHARMACOLOGY, 2001, 59 (04) :814-824

[5] GABA-Induced Intersubunit Conformational Movement in the GABAA Receptor α1M1-β2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site [J].

Bali, Moez ;

Jansen, Michaela ;

Akabas, Myles H. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (10) :3083-3092

[6] The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid [J].

Belelli, D ;

Lambert, JJ ;

Peters, JA ;

Wafford, K ;

Whiting, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :11031-11036

[7] Extrasynaptic GABAA receptors of thalamocortical neurons:: A molecular target for hypnotics [J].

Belelli, D ;

Peden, DR ;

Rosahl, TW ;

Wafford, KA ;

Lambert, JJ .

JOURNAL OF NEUROSCIENCE, 2005, 25 (50) :11513-11520

[8] Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function [J].

Belelli, Delia ;

Harrison, Neil L. ;

Maguire, Jamie ;

Macdonald, Robert L. ;

Walker, Matthew C. ;

Cope, David W. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (41) :12757-12763

[9] Anesthetics Discriminate Between Tonic and Phasic γ-Aminobutyric Acid Receptors on Hippocampal CA1 Neurons [J].

Bieda, Mark C. ;

Su, Henry ;

Maclver, M. Bruce .

ANESTHESIA AND ANALGESIA, 2009, 108 (02) :484-490

[10] An isoflurane- and alcohol-insensitive mutant GABAA receptor α1 subunit with near-normal apparent affinity for GABA:: Characterization in heterologous systems and production of knockin mice [J].

Borghese, C. M. ;

Werner, D. F. ;

Topf, N. ;

Baron, N. V. ;

Henderson, L. A. ;

Boehm, S. L., II ;

Blednov, Y. A. ;

Saad, A. ;

Dai, S. ;

Pearce, R. A. ;

Harris, R. A. ;

Homanics, G. E. ;

Harrison, N. L. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 319 (01) :208-218

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