Stereoselective synthesis of β-lactams with polyaromatic imines:: Entry to new and novel anticancer agents

被引：194

作者：

Banik, I ^{[1
]}

Becker, FF ^{[1
]}

Banik, BK ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 01期

关键词：

D O I：

10.1021/jm0255825

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We present herein stereoselective symthesis of novel beta-lactams using polyaromatic imines following the Staudinger reaction. Consistent mechanisms for these results have been advanced. As a measure of cytotaxicity, some of these compounds have been assayed against nine human cancer cell lines. Structure-activity study has revealed that 1-N-chrysenyl and 1-N-phenanthrenyl 3-acetoxy-4-aryl-2-azetidinones have potent anticancer activity. The presence of the acetoxy group at C-3 of the beta-lactams has proven to be obligatory for their anticancer activity

引用

页码：12 / 15

页数：4

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