Implementing large-scale ENU mutagenesis screens in North America

被引：68

作者：

Clark, AT

Goldowitz, D

Takahashi, JS

Vitaterna, MH

Siepka, SM

Peters, LL

Frankel, WN

Carlson, GA

Rossant, J

Nadeau, JH

Justice, MJ

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Tennessee Mouse Genome Ctr, Statewide, TN USA

[3] Northwestern Univ, Ctr Funct Gen, Evanston, IL USA

[4] Jackson Lab, Ctr Mouse Models Heart Lung Blood & Sleep Disorde, Bar Harbor, ME 04609 USA

[5] McLaughlin Res Inst Biomed Sci, Great Falls, MT USA

[6] Ctr Modeling Human Dis, Toronto, ON, Canada

[7] Case Western Reserve Univ, Univ Hosp Cleveland, Cleveland, OH 44106 USA

来源：

GENETICA | 2004年 / 122卷 / 01期

关键词：

balancer chromosomes; Human Genome Project; Mouse Genome Project; mouse mutagenesis; phenotype screens;

D O I：

10.1007/s10709-004-1436-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A step towards annotating the mouse genome is to use forward genetics in phenotype-driven screens to saturate the genome with mutations. The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening.

引用

页码：51 / 64

页数：14

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