The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii

被引：179

作者：

Segal, G ^{[1
]}

Feldman, M ^{[1
]}

Zusman, T ^{[1
]}

机构：

[1] Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, George S Wise Fac Life Sci, IL-69978 Tel Aviv, Israel

来源：

FEMS MICROBIOLOGY REVIEWS | 2005年 / 29卷 / 01期

关键词：

Legionella; Coxiella; Icm/Dot; type-IV secretion systems;

D O I：

10.1016/j.femsre.2004.07.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Type-IV secretion systems are devices present in a wide range of bacteria (including bacterial pathogens) that deliver macromolecules (proteins and single-strand-DNA) across kingdom barriers (as well as between bacteria and into the surroundings). The type-IV secretion systems were divided into two subgroups and Legionella pneumophila and Coxiella burnetii are the only two bacteria known today to utilize a type-IVB secretion system for pathogenesis. In this review we summarized the available information concerning the icm/dot type-IVB secretion systems by comparing the two bacteria that possess this system, the proteins components of their systems as well as the homology of proteins from type-IVB secretion systems to proteins from type-IVA secretion systems. In addition, the phenotypes associated with mutants in the L. pneumophila icm/dot genes, their relations to properties of specific Icm/ Dot proteins as well as the protein substrates delivered by this system are described. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：65 / 81

页数：17

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