Solid-phase synthesis of 1,2,3,4-tetrahydro-β-carboline-containing peptidomimetics

被引：34

作者：

Li, XF

Zhang, LS ^{[1
]}

Zhang, W

Hall, SE

Tam, JP

机构：

[1] Sphinx Pharmaceut, Cambridge, MA 02139 USA

[2] Vanderbilt Univ, Dept Microbiol & Immunol, Nashville, TN 37232 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 20期

关键词：

D O I：

10.1021/ol006209z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A solid-phase method for the synthesis of 1,2,3,4-tetrahydro-beta-carboline-containing peptidomimetics has been developed. The key step in the strategy is the Pictet-Spengler condensation of a resin-bound tryptophan-containing fragment with an Fmoc-amino aldehyde.

引用

收藏

页码：3075 / 3078

页数：4

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