A protein nanocarrier from charge-conversion polymer in response to endosomal pH

被引：346

作者：

Lee, Yan

Fukushima, Shigeto

Bae, Younsoo

Hiki, Shigehiro

Ishii, Takehiko

Kataoka, Kazunori

机构：

[1] Univ Tokyo, Div Clin Biotechnol, Ctr Dis Biol & Integrat Med,Japan Sci & Technol C, Grad Sch Med,Dept Mat Engn,Ctr NanoBio Integrat,C, Tokyo 1130033, Japan

[2] Univ Tokyo, Dept Bioengn, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 17期

关键词：

D O I：

10.1021/ja071090b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new type of polyion complex (PIC) micelle was prepared from lysozyme and the block copolymer, PEG-pAsp(EDA-Cit), that can switch the charge from anionic to cationic at the endosomal pH. The charge-conversion was due to the degradation of the citraconic amide side chain at pH 5.5. This abrupt charge-conversion can make the PIC micelles promptly release the internal protein in response to the endosomal pH. This pH-sensitive charge-conversion polymer is promising for the future design of nanocarriers for early endosomal release.

引用

页码：5362 / +

页数：3

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