Particulate matter air pollution from the city of Quito, Ecuador, activates inflammatory signaling pathways invitro

被引：34

作者：

Cevallos, Victoria M. ^{[1
]}

Diaz, Valeria ^{[2
,3
]}

Sirois, Cherilyn M. ^{[1
,3
,4
]}

机构：

[1] Univ Amer, Ctr Translat Res, Quito, Ecuador

[2] Municipal Quito Metropolitan Dist, Secretariat Environm, Quito, Ecuador

[3] Univ Amer, Sch Med, Coll Hlth Sci, Quito, Ecuador

[4] Univ Tecnol Equinoccial, Eugenio Espejo Coll Hlth Sci, Ctr Biomed Res, Campus Occidental, Quito, Ecuador

来源：

INNATE IMMUNITY | 2017年 / 23卷 / 04期

关键词：

LPS; NLRP3; inflammasome; particulate matter; TLR2; TLR4; TOLL-LIKE RECEPTORS; NUCLEOTIDE-BINDING DOMAIN; INNATE IMMUNITY; NALP3; INFLAMMASOME; UTAH VALLEY; RESPONSES; EXPOSURE; PM10; MECHANISMS; TOXICITY;

D O I：

10.1177/1753425917699864

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Automobile traffic, industrial processes and natural phenomena cause notable air pollution, including gaseous and particulate contaminants, in urban centers. Exposure to particulate matter (PM) air pollution affects human health, and has been linked to respiratory, cardiovascular and neurological diseases. The mechanisms underlying inflammation in these diverse diseases, and to what extent health effects are different for PM obtained from different sources or locations, are still unclear. This study investigated the invitro toxicity of ambient course (PM10) and fine (PM2.5) particulate matter collected at seven sites in the urban and periurban zones of Quito, Ecuador. Material from all sites was capable of activating TLR2 and TLR4 signaling pathways, with differences in the activation related to particle size. Additionally, airborne particulate matter from Quito is an effective activator of the NLRP3 inflammasome.

引用

页码：392 / 400

页数：9

共 72 条

[61]

In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential - the RAPTES project [J].