Marine pharmacology in 2003-4:: Marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities;: affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action

被引:134
作者
Mayer, Alejandro M. S.
Rodriguez, Abimael D.
Berlinck, Roberto G. S.
Hamann, Mark T.
机构
[1] Midwestern Univ, Dept Pharmacol, Chicago Coll Osteopath Med, Downers Grove, IL 60515 USA
[2] Univ Puerto Rico, Dept Chem, Rio Piedras, PR 00931 USA
[3] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
[4] Univ Mississippi, Sch Pharm, University, MS 38677 USA
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 2007年 / 145卷 / 04期
关键词
drug-leads; marine; metabolites; natural products; pharmacology; review; toxicology;
D O I
10.1016/j.cbpc.2007.01.015
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The current marine pharmacology review that covers the peer-reviewed literature during 2003 and 2004 is a sequel to the authors' 1998-2002 reviews, and highlights the preclinical pharmacology of 166 marine chemicals derived from a diverse group of marine animals, algae, fungi and bacteria. Anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antiprotozoal, antituberculosis or antiviral activities were reported for 67 marine chemicals. Additionally 45 marine compounds were shown to have significant effects on the cardiovascular, immune and nervous system as well as possessing anti-inflammatory effects. Finally, 54 marine compounds were reported to act on a variety of molecular targets and thus may potentially contribute to several pharmacological classes. Thus, during 2003-2004, research on the pharmacology of marine natural products which involved investigators from Argentina, Australia, Brazil, Belgium, Canada, China, France, Germany, India, Indonesia, Israel, Italy, Japan, Mexico, Morocco, the Netherlands, New Zealand, Norway, Panama, the Philippines, Portugal, Russia, Slovenia, South Korea, Spain, Thailand, Turkey, United Kingdom, and the United States, contributed numerous chemical leads for the continued global search for novel therapeutic agents with broad spectrum activity. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:553 / 581
页数:29
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