Asymmetric synthesis of anticancer β-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate

被引：103

作者：

Banik, Bimal K. ^{[1
]}

Banik, Indrani ^{[1
,2
]}

Becker, Frederick F. ^{[2
]}

机构：

[1] Univ Texas Pan Amer, Dept Chem, Edinburg, TX 78539 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Mol Pathol, Unit 951, Houston, TX 77504 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 02期

基金：

美国国家卫生研究院;

关键词：

beta-Lactams; Anticancer agents; Asymmetric synthesis; Carbohydrate; Staudinger reaction; In vitro tests; POLYCYCLIC AROMATIC-COMPOUNDS; MEDIATED FACILE SYNTHESIS; STEREOSELECTIVE SYNTHESIS; BIOLOGICAL EVALUATION; ANALOGS; CYCLOADDITION; IMINES; AGENTS;

D O I：

10.1016/j.ejmech.2009.11.024

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

We describe herein asymmetric synthesis of a novel anticancer beta-lactam following Staudinger reaction with chiral carbohydrate as the ketene component with an achiral imine. The in vitro cytotoxicity studies of these beta-lactams are also reported here. (C) 2009 Published by Elsevier Masson SAS.

引用

页码：846 / 848

页数：3

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