Design strategies for the creation of artificial metalloenzymes

被引：104

作者：

Heinisch, Tillmann ^{[1
]}

Ward, Thomas R. ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2010年 / 14卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

SUBSTITUTED CARBONIC-ANHYDRASE; DIRECTED EVOLUTION; ASYMMETRIC HYDROGENATION; ACTIVE-SITE; IN-VITRO; PROTEIN; CATALYSIS; ENZYMES; BIOCATALYSTS; SPECIFICITY;

D O I：

10.1016/j.cbpa.2009.11.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, several complementary strategies have been implemented for the creation and optimization of artificial metalloenzymes. Selected examples outline the pros and cons of five different approaches. catalytic antibodies, computational design, directed evolution, artificial metalcofactors and DNAzymes

引用

收藏

页码：184 / 199

页数：16

相关论文

共 63 条

[1] In the light of directed evolution: Pathways of adaptive protein evolution [J].

Bloom, Jesse D. ;

Arnold, Frances H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 :9995-10000

[2] DNA-based asymmetric catalysis: Sequence-dependent rate acceleration and enantioselectivity [J].

Boersma, Arnold J. ;

Klijn, Jaap E. ;

Feringa, Ben L. ;

Roelfes, Gerard .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (35) :11783-11790

[3] Enantioselective Friedel-Crafts Reactions in Water Using a DNA-Based Catalyst [J].

Boersma, Arnold J. ;

Feringa, Ben L. ;

Roelfes, Gerard .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (18) :3346-3348

[4] A site-selective dual anchoring strategy for artificial metalloprotein design [J].

Carey, JR ;

Ma, SK ;

Pfister, TD ;

Garner, DK ;

Kim, HK ;

Abramite, JA ;

Wang, ZL ;

Guo, ZJ ;

Lu, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (35) :10812-10813

[5] TUNING THE ACTIVITY OF AN ENZYME FOR UNUSUAL ENVIRONMENTS - SEQUENTIAL RANDOM MUTAGENESIS OF SUBTILISIN-E FOR CATALYSIS IN DIMETHYLFORMAMIDE [J].

CHEN, KQ ;

ARNOLD, FH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (12) :5618-5622

[6] DNA-Based catalytic enantioselective Michael reactions in water [J].

Coquiere, David ;

Feringa, Ben L. ;

Roelfes, Gerard .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (48) :9308-9311

[7] Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold [J].

Coquiere, David ;

Bos, Jeffrey ;

Beld, Joris ;

Roelfes, Gerard .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (28) :5159-5162

[8] X-ray structure and designed evolution of an artificial transfer hydrogenase [J].

Creus, Marc ;

Pordea, Anca ;

Rossel, Thibaud ;

Sardo, Alessia ;

Letondor, Christophe ;

Ivanova, Anita ;

Le Trong, Isolde ;

Stenkamp, Ronald E. ;

Ward, Thomas R. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (08) :1400-1404

[9] DNA-based hydrolytic kinetic resolution of epoxides [J].

Dijk, Ewold W. ;

Feringa, Ben L. ;

Roelfes, Gerard .

TETRAHEDRON-ASYMMETRY, 2008, 19 (20) :2374-2377

[10] Transforming carbonic anhydrase into epoxide synthase by metal exchange [J].

Fernandez-Gacio, Ana ;

Codina, Antonio ;

Fastrez, Jacques ;

Riant, Olivier ;

Soumillion, Patrice .

CHEMBIOCHEM, 2006, 7 (07) :1013-1016

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