Design strategies for the creation of artificial metalloenzymes

被引：104

作者：

Heinisch, Tillmann ^{[1
]}

Ward, Thomas R. ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2010年 / 14卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

SUBSTITUTED CARBONIC-ANHYDRASE; DIRECTED EVOLUTION; ASYMMETRIC HYDROGENATION; ACTIVE-SITE; IN-VITRO; PROTEIN; CATALYSIS; ENZYMES; BIOCATALYSTS; SPECIFICITY;

D O I：

10.1016/j.cbpa.2009.11.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, several complementary strategies have been implemented for the creation and optimization of artificial metalloenzymes. Selected examples outline the pros and cons of five different approaches. catalytic antibodies, computational design, directed evolution, artificial metalcofactors and DNAzymes

引用

收藏

页码：184 / 199

页数：16

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