Total Synthesis of the Polycyclic Fungal Metabolite (±)-Communesin F

被引：103

作者：

Liu, Peng ^{[1
]}

Seo, Jae Hong ^{[1
]}

Weinreb, Steven M. ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 11期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

alkaloids; Heck reactions; natural products; nitrogen heterocycles; total synthesis; PENICILLIUM-EXPANSUM LINK; BIOMIMETIC APPROACH; COMMUNESIN; PEROPHORAMIDINE; NOMOFUNGIN; ALKALOIDS; BIOSYNTHESIS;

D O I：

10.1002/anie.200906818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) What the Heck: The heptacyclic fungal alkaloid communesin F was the target of a total synthesis featuring a rare example of an intramolecular Heck cyclization of a tetrasubstituted alkene, a reductive cyclization of an N-Boc aniline, a stereoselective C allylation of a lactam, and an azide reduction/N-Boc-d-lactam ring opening sequence (see scheme, BOM=benzyloxymethyl). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2000 / 2003

页数：4

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