Separation of absorption and scattering profiles in spectroscopic optical coherence tomography using a least-squares algorithm

被引：63

作者：

Xu, CY ^{[1
]}

Marks, DL ^{[1
]}

Do, MN ^{[1
]}

Boppart, SA ^{[1
]}

机构：

[1] Univ Illinois, Beckman Inst, Dept Elect & Comp Engn, Urbana, IL 61801 USA

来源：

OPTICS EXPRESS | 2004年 / 12卷 / 20期

关键词：

D O I：

10.1364/OPEX.12.004790

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

In spectroscopic optical coherence tomography, it is important and useful to separately estimate the absorption and the scattering properties of tissue. In this paper, we propose a least-squares fitting algorithm to separate absorption and scattering profiles when near-infrared absorbing dyes are used. The algorithm utilizes the broadband Ti:sapphire laser spectrum together with joint time-frequency analysis. Noise contribution to the final estimation was analyzed using simulation. The validity of our algorithm was demonstrated using both single-layer and multi-layer tissue phantoms. (C) 2004 Optical Society of America.

引用

页码：4790 / 4803

页数：14

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