Gadolinium meets medicinal chemistry: MRI contrast agent development

被引：64

作者：

Zhang, ZD ^{[1
]}

Nair, SA ^{[1
]}

McMurry, TJ ^{[1
]}

机构：

[1] EPIX Pharmaceut Inc, Cambridge, MA 02142 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2005年 / 12卷 / 07期

关键词：

MRI; contrast agents; gadolinium; extracellular contrast agents; liver contrast agents; vascular contrast agents (blood pool contrast agents); responsive or 'smart' agents;

D O I：

10.2174/0929867053507379

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnetic resonance imaging (MRI) contrast agents are utilized adjunctively to enhance the contrast between normal and abnormal structures on MRI scans. Along with the rapid evolution of the field has come a new appreciation for the medicinal chemistry of this unique class of metallopharmaceuticals. The efficacy of MRI agents is a complex function of chemical, biophysical, and pharmacological properties, which must be married in a package of exquisite safety. This report illustrates the wide range of medicinal chemistry relevant to existing agents that are either approved or in clinical development, as well as concepts, which may result in exciting new pharmaceuticals in the future.

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页码：751 / 778

页数：28

相关论文

共 109 条

[81] COMPARISON OF GADOLINIUM CY(2)DOTA, A NEW HEPATOBILIARY AGENT, AND GADOLINIUM HP-DO3A, AN EXTRACELLULAR AGENT, IN HEALTHY LIVER AND METASTATIC DISEASE [J].

RUNGE, VM ;

WELLS, JW ;

WILLIAMS, NM .

INVESTIGATIVE RADIOLOGY, 1995, 30 (02) :123-130

[82] A comparison of two MR hepatobiliary gadolinium chelates: Gd-BOPTA and Gd-EOB-DTPA [J].

Runge, VM .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1998, 22 (04) :643-650

[83]

Saeed M, 2000, J MAGN RESON IMAGING, V12, P890

[84] Contrast-enhanced MR imaging of the liver: Comparison between Gd-BOPTA and Mangafodipir [J].

Schima, W ;

Petersein, J ;

Hahn, PF ;

Harisinghani, M ;

Halpern, E ;

Saini, S .

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1997, 7 (01) :130-135

[85] Synthesis and physicochemical characterization of a new gadolinium chelate:: The liver-specific magnetic resonance imaging contrast agent Gd-EOB-DTPA [J].

Schmitt-Willich, H ;

Brehm, M ;

Ewers, CLJ ;

Michl, G ;

Müller-Fahrnow, A ;

Petrov, O ;

Platzek, J ;

Radüchel, B ;

Sülzle, D .

INORGANIC CHEMISTRY, 1999, 38 (06) :1134-1144

[86]

SCHUHMANNGIAMPIERI G, 1993, ARZNEIMITTELFORSCH, V43-2, P927

[87] Pharmacokinetics of the liver-specific contrast agent Gd-EOB-DTPA in relation to contrast-enhanced liver imaging in humans [J].

SchuhmannGiampieri, G ;

Mahler, M ;

Roll, G ;

Maibauer, R ;

Schmitz, S .

JOURNAL OF CLINICAL PHARMACOLOGY, 1997, 37 (07) :587-596

[88] INVIVO AND INVITRO EVALUATION OF GD-DTPA-POLYLYSINE AS A MACROMOLECULAR CONTRAST AGENT FOR MAGNETIC-RESONANCE-IMAGING [J].

SCHUHMANNGIAMPIERI, G ;

SCHMITTWILLICH, H ;

FRENZEL, T ;

PRESS, WR ;

WEINMANN, HJ .

INVESTIGATIVE RADIOLOGY, 1991, 26 (11) :969-974

[89] PRECLINICAL EVALUATION OF GD-EOB-DTPA AS A CONTRAST AGENT IN MR IMAGING OF THE HEPATOBILIARY SYSTEM [J].

SCHUHMANNGIAMPIERI, G ;

SCHMITTWILLICH, H ;

PRESS, WR ;

NEGISHI, C ;

WEINMANN, HJ ;

SPECK, U .

RADIOLOGY, 1992, 183 (01) :59-64

[90] ANGIOGRAPHIC PROPERTIES OF GD-DTPA-24-CASCADE-POLYMER - A NEW MACROMOLECULAR MR CONTRAST AGENT [J].

SCHWICKERT, HC ;

ROBERTS, TPL ;

MUHLER, A ;

STISKAL, M ;

DEMSAR, F ;

BRASCH, RC .

EUROPEAN JOURNAL OF RADIOLOGY, 1995, 20 (02) :144-150

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