PTH battles TGF-β in bone

被引：21

作者：

Atfi, Azeddine ^{[1
,2
]}

Baron, Roland ^{[2
,3
]}

机构：

[1] Hop St Antoine, NSERM, UMRS 938, F-75571 Paris, France

[2] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med,Endocrine Unit, Boston, MA 02115 USA

来源：

NATURE CELL BIOLOGY | 2010年 / 12卷 / 03期

关键词：

PARATHYROID-HORMONE; RECEPTOR;

D O I：

10.1038/ncb0310-205

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-beta). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-beta type II receptor (T beta RII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-beta and PTH signalling in vivo.

引用

页码：205 / 207

页数：4

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