Solid phase synthesis of benzylamine-derived sulfonamide library

被引:29
作者
Kim, SW [1 ]
Hong, CY [1 ]
Lee, K [1 ]
Lee, EJ [1 ]
Koh, JS [1 ]
机构
[1] LG Chem Ltd, Biotech Res Inst, Taejon 305380, South Korea
关键词
D O I
10.1016/S0960-894X(98)00114-0
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Using solid phase synthesis, a library has been constructed of benzylamine-derived sulfonamides which have strong inhibitory activity against the blood coagulant thrombin. The library compounds were obtained in good yield and high purity; four of these thrombin inhibitors showed nanomolar potency (Ki 600-10 nM). (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:735 / 738
页数:4
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