Solid phase synthesis of benzylamine-derived sulfonamide library

被引：29

作者：

Kim, SW ^{[1
]}

Hong, CY ^{[1
]}

Lee, K ^{[1
]}

Lee, EJ ^{[1
]}

Koh, JS ^{[1
]}

机构：

[1] LG Chem Ltd, Biotech Res Inst, Taejon 305380, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(98)00114-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using solid phase synthesis, a library has been constructed of benzylamine-derived sulfonamides which have strong inhibitory activity against the blood coagulant thrombin. The library compounds were obtained in good yield and high purity; four of these thrombin inhibitors showed nanomolar potency (Ki 600-10 nM). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：735 / 738

页数：4

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