Anticancer activity of opened arene ruthenium metalla-assemblies

被引：75

作者：

Barry, Nicolas P. E. ^{[1
]}

Zava, Olivier ^{[2
]}

Furrer, Julien ^{[3
]}

Dyson, Paul J. ^{[2
]}

Therrien, Bruno ^{[1
]}

机构：

[1] Univ Neuchatel, Inst Chem, CH-2000 Neuchatel, Switzerland

[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[3] Univ Neuchatel, Serv Analyt Facultaire, CH-2009 Neuchatel, Switzerland

来源：

DALTON TRANSACTIONS | 2010年 / 39卷 / 22期

基金：

瑞士国家科学基金会;

关键词：

CELLULAR UPTAKE; PHASE-I; COMPLEXES; BINDING; AGENT; COORDINATION; KP1019; PORPHYRINS; COMPOUND; RELEASE;

D O I：

10.1039/c001521k

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)(2)Ru-2(OO boolean AND OO)(2)](2+) (OO boolean AND OO = oxalato, 2,5-dioxydo-1,4-benzoquinonato (dobq)) have been assembled in the presence of silver triflate. All complexes were characterised by NMR, IR and UV-visible spectroscopy and electrospray ionisation mass spectrometry. The cytotoxicities of the tetranuclear and hexanuclear ruthenium complexes have been established on ovarian A2780 and A2780cisR cancer cell lines. The compounds are quite cytotoxic, the most active metalla-assembly being [Ru-6(p-cymene)(6)(dobq)(3)(tpp)(2)](6+), with IC50 values of 2.1 mu M and 3.8 mu M against A2780 and A2780cisR cells, respectively.

引用

页码：5272 / 5277

页数：6

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