Glycopeptide-functionalized gold nanoparticles for antibody induction against the tumor associated mucin-1 glycoprotein

被引：48

作者：

Cai, Hui ^{[1
]}

Degliangeli, Federica ^{[2
]}

Palitzsch, Bjoern ^{[3
]}

Gerlitzki, Bastian ^{[4
]}

Kunz, Horst ^{[3
]}

Schmitt, Edgar ^{[4
]}

Fiammengo, Roberto ^{[2
]}

Westerlind, Ulrika ^{[1
]}

机构：

[1] Leibniz Inst Analyt Sci, Gesell Forderung Analyt Wissensch eV ISAS, Otto Hahn Str 6b, D-44227 Dortmund, Germany

[2] IIT, Ctr Biomol Nanotechnol UniLe, Via Barsanti, I-73010 Lecce, Italy

[3] Johannes Gutenberg Univ Mainz, Inst Organ Chem, Duesbergweg 10-14, D-55128 Mainz, Germany

[4] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Immunol, Langenbeckstr 1,Geb 708, D-55101 Mainz, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2016年 / 24卷 / 05期

关键词：

Glycopeptides; Nanoparticles; Vaccines; Antibodies; Cancer; SYNTHETIC ANTITUMOR VACCINES; IMMUNE-RESPONSE; CANCER-IMMUNOTHERAPY; MUC1; GLYCOPEPTIDES; DENDRITIC CELLS; IN-VIVO; ANTIGENS; BREAST; GLYCOSYLATION; IMPROVE;

D O I：

10.1016/j.bmc.2016.01.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We report the preparation of gold nanoparticle (AuNP)-based vaccine candidates against the tumor-associated form of the mucin-1 (MUC1) glycoprotein. Chimeric peptides, consisting of a glycopeptide sequence derived from MUC1 and the T-cell epitope P30 sequence were immobilized on PEGylated AuNPs and the ability to induce selective antibodies in vivo was investigated. After immunization, mice showed significant MHC-II mediated immune responses and their antisera recognized human MCF-7 breast cancer cells. Nanoparticles designed according to this report may become key players in the development of anticancer vaccines. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1132 / 1135

页数：4

共 32 条

[1]

Synthetically defined glycoprotein vaccines: current status and future directions [J].

Adamo, Roberto ;

Nilo, Alberto ;

Castagner, Bastien ;

Boutureira, Omar ;

Berti, Francesco ;

Bernardes, Gonalo J. L. .

CHEMICAL SCIENCE, 2013, 4 (08) :2995-3008

[2]

Gold Nanoparticles Displaying Tumor-Associated Self-Antigens as a Potential Vaccine for Cancer Immunotherapy [J].

Ahn, Sukyung ;

Lee, In-Hyun ;

Kang, Sukmo ;

Kim, Daejin ;

Choi, Minsuk ;

Saw, Phei Er ;

Shin, Eui-Cheol ;

Jon, Sangyong .

ADVANCED HEALTHCARE MATERIALS, 2014, 3 (08) :1194-1199

[3]

Gold nanoparticle mediated cancer immunotherapy [J].

Almeida, Joao Paulo Mattos ;

Figueroa, Elizabeth Raquel ;

Drezek, Rebekah Anna .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2014, 10 (03) :503-514

[4]

Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[5]

Design and Synthesis of Multifunctional Gold Nanoparticles Bearing Tumor-Associated Glycopeptide Antigens as Potential Cancer Vaccines [J].

Brinas, Raymond P. ;

Sundgren, Andreas ;

Sahoo, Padmini ;

Morey, Susan ;

Rittenhouse-Olson, Kate ;

Wilding, Greg E. ;

Deng, Wei ;

Barchi, Joseph J., Jr. .

BIOCONJUGATE CHEMISTRY, 2012, 23 (08) :1513-1523

[6]

Pathways of O-glycan biosynthesis in cancer cells [J].

Brockhausen, I .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1999, 1473 (01) :67-95

[7]

MECHANISMS UNDERLYING ABERRANT GLYCOSYLATION OF MUC1 MUCIN IN BREAST-CANCER CELLS [J].

BROCKHAUSEN, I ;

YANG, JM ;

BURCHELL, J ;

WHITEHOUSE, C ;

TAYLORPAPADIMITRIOU, J .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 233 (02) :607-617

[8]

O-linked glycosylation in the mammary gland: Changes that occur during malignancy [J].

Burchell, JM ;

Mungul, A ;

Taylor-Papadimitriou, J .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2001, 6 (03) :355-364

[9]

Self-Adjuvanting Synthetic Antitumor Vaccines from MUC1 Glycopeptides Conjugated to T-Cell Epitopes from Tetanus Toxoid [J].

Cai, Hui ;

Chen, Mei-Sha ;

Sun, Zhan-Yi ;

Zhao, Yu-Fen ;

Kunz, Horst ;

Li, Yan-Mei .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (23) :6106-6110

[10]

Variation of the Glycosylation Pattern in MUC1 Glycopeptide BSA Vaccines and Its Influence on the Immune Response [J].

Cai, Hui ;

Huang, Zhi-Hua ;

Shi, Lei ;

Sun, Zhan-Yi ;

Zhao, Yu-Fen ;

Kunz, Horst ;

Li, Yan-Mei .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (07) :1719-1723

← 1 2 3 4 →