Potential of nanofiber matrix as tissue-engineering scaffolds

被引:796
作者
Ma, ZW
Kotaki, M
Inai, R
Ramakrishna, S
机构
[1] Natl Univ Singapore, Nanosci & Nanotechnol Initiat, Singapore 117576, Singapore
[2] Natl Univ Singapore, Div Bioengn, Singapore 117576, Singapore
[3] Natl Univ Singapore, Dept Mech Engn, Singapore 117576, Singapore
来源
TISSUE ENGINEERING | 2005年 / 11卷 / 1-2期
关键词
D O I
10.1089/ten.2005.11.101
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Tissue-engineering scaffolds should be analogous to native extracellular matrix (ECM) in terms of both chemical composition and physical structure. Polymeric nanofiber matrix is similar, with its nanoscaled nonwoven fibrous ECM proteins, and thus is a candidate ECM-mimetic material. Techniques such as electrospinning to produce polymeric nanofibers have stimulated researchers to explore the application of nanofiber matrix as a tissue-engineering scaffold. This review covers the preparation and modification of polymeric nanofiber matrix in the development of future tissue-engineering scaffolds. Major emphasis is also given to the development and applications of aligned, core shell-structured, or surface-functionalized polymer nanofibers. The potential application of polymer nanofibers extends far beyond tissue engineering. Owing to their high surface area, functionalized polymer nanofibers will find broad applications as drug delivery carriers, biosensors, and molecular filtration membranes in future.
引用
收藏
页码:101 / 109
页数:9
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